81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Hochschulprofessor. Haass started to work on Alzheimer's disease (AD) in 1990 at a time, when very little was known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion in this field that Aß may be produced from its precursor hinein a physiologically normal pathway and not necessarily in a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding was a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved in generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production in patients.
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features. Performance Performance
You want to get your driving licence rein Munich as soon as possible, rein an enjoyable and straightforward way? If so, you’ve come to exactly the right place! We are a Munich driving school and guarantee you all-round support hinein theory, practice and other aspects of Schulung.
We work on the molecular and cellular mechanisms of neurodegeneration with a strong focus on Alzheimer’s disease and related disorders. We are searching for therapeutic targets within the amyloid cascade. Secretases, amyloid metabolism and microglial function are within the focus of ur research.
Is it possible for a good driving student to register for the test after having lessons only rein special driving situations? No, that is not possible because of the legal regulations.
You can do following driving classes with us. Click on each class to get more information. Class B
Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass welches the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which was overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He welches also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved in brain development (such as myelination and cell differentiation) but also provided the Stützpunkt for several current therapeutic approaches.
Sie können zigeunern rein aller Ruhe ohne persönlichen oder beruflichen Nervosität auf die Prüfung vorbereiten zumal sie erfolgreich Durchführen.
If you are lacking driving practice or simply haven't driven a car in a long time and have got out of the habit, we can help you get back into it with a few refresher lessons.
Together with an interdiziplinary team Webseite he uncovered the molecular mechanisms of Alzheimer's disease and identified target molecules for therapeutic treatment.
Der markante Bau mit den drei hohen Türmen wurde aus massiven Sandsteinblöcken erbaut und besitzt eine dekorative Rosette und ein Giebeldach.
Christian Haass, Professor of Metabolic Biochemistry at LMU Munich and spokesperson for the DZNE Munich, is known for his groundbreaking research rein Alzheimer's disease. His work focuses on the molecular and cellular mechanisms of this disease hinein order to gain fundamental insights into its development.
Next to the Ostfriedhof bus and tram stop Can I take a trial lesson hinein the theoretical course hinein order to get an impression of the atmosphere?
At the earliest, approx. 3 – 5 months before your 18th birthday, depending on whether you wish to do the theoretical and the practical Weiterbildung one after the other or at the same time.
The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".